Mitochondrial redox metabolism in aging: Effect of exercise interventions
Hai Bo a,b, Ning Jiang a, Li Li Ji a,c, Yong Zhang a,*
a Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Department of Health & Exercise Science, Tianjin University of Sport,
Tianjin 300381, China b Department of Military Training Medicines, Logistics University of Chinese People’s Armed Police Force, Tianjin 300162, China c Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Abstract Mitochondrial redox metabolism has long been recognized as being central to the effects of aging and the development of age-related pathologies in the major oxidative organs. Consistent evidence has shown that exercise is able to retard the onset and impede the progression of aging by modifying mitochondrial oxidanteantioxidant homeostasis. Here we provide a broad overview of the research evidence showing the relationship between mitochondrial redox metabolism, aging and exercise. We address part aspects of mitochondrial reactive oxygen species (ROS) metabolism, from superoxide production to ROS detoxification, especially antioxidant enzymes and uncoupling protein. Furthermore, we describe mitochondrial remodeling response to aging and exercise, which is accompanied by bioenergetics and redox regulation. In addition, potential mechanisms for redox signaling involved in mitochondrial remodeling and redox metabolism regulation are also reviewed.
Significant point: Oxidative stress and mitochondrial dysfunction play key roles in aging. However exercise induced ROS may actually work as potentially lifespan-promoting signaling molecules which lead to amelioration of mitochondrial remodeling. This should be defined as mitochondrial ROS hormesis.
Corresponding Authors: Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Department of Health & Exercise Science, Tianjin University of Sport,
Tianjin 300381, China
Cite this article:
Hai Bo,Ning Jiang,Li Li Ji et al. Mitochondrial redox metabolism in aging: Effect of exercise interventions[J]. Journal of Sport and Health Science, 2013, 2(2): 67-74.