Mitochondrial redox metabolism in aging: Effect of exercise interventions
Hai Bo, Ning Jiang, Li Li Ji, Yong Zhang
a Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Department of Health & Exercise Science, Tianjin University of Sport, Tianjin 300381, China; b Department of Military Training Medicines, Logistics University of Chinese People's Armed Police Force, Tianjin 300162, China; c Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Abstract Mitochondrial redox metabolism has long been recognized as being central to the effects of aging and the development of age-related pathologies in the major oxidative organs. Consistent evidence has shown that exercise is able to retard the onset and impede the progression of aging by modifying mitochondrial oxidant-antioxidant homeostasis. Here we provide a broad overview of the research evidence showing therelationship between mitochondrial redox metabolism, aging and exercise. We address part aspects of mitochondrial reactive oxygen species(ROS) metabolism, from super oxide production to ROS detoxification, especially antioxidant enzymes and uncoupling protein. Furthermore, we describe mitochondrial remodeling response to aging and exercise, which is accompanied by bioenergetics and red ox regulation. In addition,potential mechanisms for re dox signaling involved in mitochondrial remodeling and re dox metabolism regulation are also reviewed.
This work was supported by research grants from the National Natural Science Foundation of China(No.31110103919, 31200894,31000523,30771048,30470837,31071040,and 30270638);Tianjin Municipal Sci-tech-innovation Base Project (No.10SYSYJC28400);Tianjin Science and Technology Planning Project(No.12JCQNJC07900) and General Administration of Sport of China Basic Project(No.10B058)